(University of Delhi)
Benito Juarez Road, New Delhi - 110021
(Phone No. - 011-2411 2196 : Email - principal@svc.ac.in)
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Sri Venkateswara College (University of Delhi) Benito Juarez Road, New Delhi - 110021 (Phone No. - 011-2411 2196 : Email - principal@svc.ac.in) |
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| Print Date : 29-10-2025 | ||||||||
| 1. Personal Profile | ||||||
| Title: Dr. First Name: VANDANA Last Name: MALHOTRA |
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| Designation: ASSOCIATE PROFESSOR Mobile No. ---------- | ||||||
| Phone No. (Office) ---------- Phone No. (Residence): ---------- | ||||||
| Email: vandana.malhotra@svc.ac.in Webpage: ---------- | ||||||
| Facebook: ---------- Twitter: ---------- | ||||||
| LinkedIn: ---------- Instagram: ---------- | ||||||
| Youtube: ---------- Research Gate Link: ---------- | ||||||
| Google Scholar Link: ---------- | ||||||
| Address: ---------- | ||||||
| 2. Educational Qualifications | ||
| Degree/ Certification | Institution | Year |
| B.Sc | Daulat Ram College, University of Delhi | 1993 |
| M.Sc | Madurai Kamaraj University | 1995 |
| PhD | All India Institute of Medical Sciences, New Delhi | 2002 |
| NET/JRF | NA | 1995 |
| GATE score | NA | 1996 |
| ARSB NET JRF | Na | 1995 |
| 3. Career Profile & Administrative Assignments | ||||
| Category | Role/ Designation | Department/ Committee | Date From - To | Remarks |
|---|---|---|---|---|
| ADMINISTRATIVE ASSIGNMENTS | MEMBER | HOSTEL COMMITTEE Sri Venkateswara College University of Delhi | 01.Aug.2023 - 08.Oct.2025 | |
| 4. Other Profiles |
| Other Profile Name/ Description |
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| 5. Research Guidance | ||||
| Year | Guide For | Title of the Dissertation/ Thesis | Scholar Name | Status |
|---|---|---|---|---|
| 2027 | Ph. D. | Understanding the regulation of Toxin-Antitoxin Modules in Mycobacterium tuberculosis | Shafinaz Rahman Sarah | Pursuing |
| 2028 | Ph. D. | Dissecting TCS-Pkn Signaling Networks in Mycobacterium tuberculosis | Abhishek Garg | Pursuing |
| 6. Research Projects | |||||
| Year | Title of Project | Sponsorship Agency | Duration | Amount Sanctioned | Date of Sanction |
|---|---|---|---|---|---|
| 2015 | High-throughput substrate profiling of Mycobacterium tuberculosis Ser/Thr Protein kinase K | Department of Biotechnology, Govt of India | 3 years | 45.0 Lakhs | 06.Feb.2015 |
| 2016 | To Develop Novel FRET Based Tools for Detecting In Vivo Localization & Phosphorylation of M. tuberculosis Signaling Proteins | Cluster Innovation Center, DU | 3 years | 20.14 Lakhs | 01.Jul.2016 |
| 2016 | Delayed Sleep Phase Disorder (DSPD): A Public Health Initiative Targeting Youth in Urban Areas, Creating Socio-Legal Awareness and Development of a Rapid Mobile Diagnostic Test | Cluster Innovation Center, DU | 3 years | 24 Lakhs | 01.Jul.2016 |
| 2021 | Understanding the Role of Ser/Thr Protein Kinases in the regulation of Toxin-Antitoxin loci in Mycobacterium tuberculosis | Department of Biotechnology, Govt of India | 3 years | 123 Lakhs | 15.Jul.2021 |
| 7. Publications | |||||
| Category | Publication Name | Title | Name of Author | Reference Link/ DOI Link |
Publication (Month-Year) |
|---|---|---|---|---|---|
| JOURNAL PAPER (International) |
Characterization of a two-component System, devR-devS, of Mycobacterium tuberculosis | Tubercle and Lung Disease | 21. Dasgupta, N., V. Kapur, K.K. Singh, T. K. Das, S. Sachdeva, K. Jyothisri and J. S. Tyagi (Joint Author) |
https://doi.org/10.1054/tuld.2000.0240 | May 2000 |
| JOURNAL PAPER (International) |
Disruption of response regulator gene, devR leads to attenuation in virulence of Mycobacterium tuberculosis | FEMS Microbiology Letters | Vandana Malhotra, Deepak Sharma, VD Ramanathan, H Shakila, Deepak K Saini, Soumitesh Chakravorty, Taposh K Das, Qing Li, Richard F Silver, PR Narayanan, Jaya Sivaswami Tyagi (First Author) |
https://doi.org/10.1016/S0378-1097(04)00002-3 | March 2004 |
| JOURNAL PAPER (International) |
Cross Talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis | FEBS Letters | Saini, D. K., V. Malhotra, J.S. Tyagi. (Joint Author) |
https://doi.org/10.1016/j.febslet.2004.02.092 | April 2004 |
| JOURNAL PAPER (International) |
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia responsive in the absence of the DNA binding domain of DevR. | Microbiology | 19. Saini, D. K., V. Malhotra, D. Dey, N. Pant, T. K. Das and J. S. Tyagi. (Joint Author) |
DOI 10.1099/mic.0.26218-0 | April 2004 |
| JOURNAL PAPER (International) |
DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: Links to asparagine metabolism | Tuberculosis | Vandana Malhotra, Jaya Sivaswami Tyagi, Josephine E Clark-Curtiss (First Author, Corresponding Author) |
https://doi.org/10.1016/j.tube.2008.12.003 | March 2009 |
| JOURNAL PAPER (International) |
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation | Microbiology | Vandana Malhotra, Lourdes T Arteaga-Cortes, Gwendolyn Clay, Josephine E Clark-Curtiss (First Author, Corresponding Author) |
https://doi.org/10.1099/mic.0.040675-0 | September 2010 |
| JOURNAL PAPER (International) |
The prrAB Two-Component System Is Essential for Mycobacterium tuberculosis Viability and Is Induced under Nitrogen-Limiting Conditions | Journal of Bacteriology | Shelley E Haydel, Vandana Malhotra, Garrett L Cornelison, Josephine E Clark-Curtiss (Joint Author) |
https://doi.org/10.1128/jb.06258-11 | January 2012 |
| JOURNAL PAPER (International) |
Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control | Journal of Bacteriology | Vandana Malhotra, Blessing P Okon, Josephine E Clark-Curtiss (First Author, Corresponding Author) |
https://doi.org/10.1128/jb.00585-12 | August 2012 |
| JOURNAL PAPER (International) |
Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism | Journal of Biological Chemistry | Vandana Malhotra, Ruchi Agrawal, Tammi R Duncan, Deepak K Saini, Josephine E Clark-Curtiss (First Author, Corresponding Author) |
https://doi.org/10.1074/jbc.M114.591800 | March 2015 |
| JOURNAL PAPER (International) |
The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition | Journal of Microbiology | Shaleen B Korch, Vandana Malhotra, Heidi Contreras, Josephine E Clark-Curtiss (Joint Author) |
https://doi.org/10.1007/s12275-015-0741-3 | December 2015 |
| JOURNAL PAPER (International) |
Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis | Journal of Biological Chemistry | Atul Vashist, Vandana Malhotra, Gunjan Sharma, Jaya Sivaswami Tyagi, Josephine E Clark-Curtiss (First Author, Corresponding Author) |
https://doi.org/10.1074/jbc.RA118.004331 | October 2018 |
| JOURNAL PAPER (International) |
Acetylation of Response Regulator Proteins, TcrX and MtrA in M. tuberculosis Tunes their Phosphotransfer Ability and Modulates Two-Component Signaling Crosstalk | Journal of Molecular Biology | Krishna Kumar Singh, Neerupma Bhardwaj, Gaurav D Sankhe, Niveda Udaykumar, Rambir Singh, Vandana Malhotra, Deepak Kumar Saini (Joint Author) |
https://doi.org/10.1016/j.jmb.2019.01.004 | March 2019 |
| JOURNAL PAPER (International) |
Cyclic di‐GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources | The FASEB journal | Vignesh Narayan Hariharan, Rahul Yadav, Chandrani Thakur, Albel Singh, Renu Gopinathan, Devendra Pratap Singh, Gaurav Sankhe, Vandana Malhotra, Nagasuma Chandra, Apoorva Bhatt, Deepak Kumar Saini (Joint Author) |
https://doi.org/10.1096/fj.202002537RR | March 2021 |
| JOURNAL PAPER (International) |
A low-prevalence single-nucleotide polymorphism in the Sensor kinase PhoR in Mycobacterium tuberculosis suppresses its autophosphatase activity and reduces pathogenic fitness: implications in Evolutionary Selection | Frontiers in Microbiology | Uchenna Watson Waturuocha, MS Krishna, Vandana Malhotra, Narendra M Dixit, Deepak Kumar Saini (Joint Author) |
https://doi.org/10.3389/fmicb.2021.724482 | August 2021 |
| JOURNAL PAPER (International) |
A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties | PLos One | D. K. Waturuocha, U. W., P. J., A., Singh, K. K., Malhotra, V., Krishna, M. S., & Saini (Joint Author) |
https://doi.org/10.1371/journal.pone.0256664 | September 2021 |
| JOURNAL PAPER (International) |
Mycobacterium tuberculosis PknK substrate profiling reveals essential transcription terminator protein Rho and two-component response regulators PrrA and MtrA as novel targets for phosphorylation | Microbiology Spectrum | Vandana Malhotra, Blessing P Okon, Akash T Satsangi, Sumana Das, Uchenna Watson Waturuocha, Atul Vashist, Josephine E Clark-Curtiss, Deepak Kumar Saini (First Author, Corresponding Author) |
https://doi.org/10.1128/spectrum.01354-21 | April 2022 |
| JOURNAL PAPER (National) |
In silico evidence for extensive Ser/Thr phosphorylation of Mycobacterium tuberculosis two-component signalling systems | Current Science | Abhishek Garg, Nimisha Khurana, Ananya Chugh, Kangna Verma, Vandana Malhotra (Corresponding Author) |
doi: 10.18520/cs/v123/i9/1159-1164 | November 2022 |
| JOURNAL PAPER (International) |
Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates | Journal of Visualized Experiments | Hiba Haris, Prachi Kumar, Vivek Bhardwaj, Sidhartha Taritla, Vandana Malhotra, Nandita Narayanasamy (Corresponding Author) |
https://dx.doi.org/10.3791/66882 | October 2024 |
| JOURNAL PAPER (International) |
Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization | mBio | Shafinaz Rahman Sarah, Abhishek Garg, Sadiyah Afroz, Shaleen Korch, Arjun Ray, Amita Gupta, Vandana Malhotra (Corresponding Author) |
https://doi.org/10.1128/mbio.01068-25 | June 2025 |
| JOURNAL PAPER (International) |
Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates. | Journal of Visualized Experiments | Haris, H., Kumar, P., Bhardwaj, V., Taritla, S., Malhotra, V., Narayanasamy, N. (Corresponding Author) |
doi:10.3791/66882 | June 2024 |
| CHAPTER (National) |
Life Science Protocol Manual | Department of Biotechnology Govt of India | Vandana Malhotra and Meeta Bhardwaj (First Author) |
January 2018 |
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| CHAPTER (National) |
Life Science Protocol Manual | Department of Biotechnology Govt of India | Nandita Narayanasamy, Vandana Malhotra (Joint Author) |
January 2018 |
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| 8. Books | ||||
| Category | Book Name | Title | Name of Author | ISSN/ ISBN Number |
|---|---|---|---|---|
| 9. Faculty Achievements | |||||
| Year | Category of Achievement | Role | National/ International etc. | Name | Date From-To |
|---|---|---|---|---|---|
| Dr. VANDANA MALHOTRA |