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Dr. VANDANA MALHOTRA

Dr. VANDANA MALHOTRA

ASSOCIATE PROFESSOR

BIO-CHEMISTRY

Emailvandana.malhotra@svc.ac.in
Educational Qualifications
Degree / CertificationInstitutionYear
PhDAll India Institute of Medical Sciences, New Delhi2002
GATE scoreNA1996
M.ScMadurai Kamaraj University1995
NET/JRFNA1995
ARSB NET JRFNa1995
B.ScDaulat Ram College, University of Delhi1993
Career Profile & Administrative Assignments
CategoryRole / DesignationDept / InstitutionPeriodRemarksAttachment
ADMINISTRATIVE ASSIGNMENTS OTHERS OTHERS Sri Venkateswara College 22.Jul.2026 – Till date
ADMINISTRATIVE ASSIGNMENTS CONVENER RESEARCH COMMITTEE Sri Venkateswara College 20.Jul.2025 – Till date The Committee for SVC Research and Innovation Activities (SVCRIA) –
ADMINISTRATIVE ASSIGNMENTS MEMBER HOSTEL COMMITTEE Sri Venkateswara College 20.Jul.2025 – Till date –
ADMINISTRATIVE ASSIGNMENTS OTHERS DEPARTMENT OF BIOCHEMISTRY Sri Venkateswara College University of Delhi 01.Jan.2025 – 15.Mar.2025 Departmental Magazine "Expressions" –
ADMINISTRATIVE ASSIGNMENTS MEMBER NIRF Sri Venkateswara College University of Delhi 01.Jul.2024 – Till date –
ADMINISTRATIVE ASSIGNMENTS MEMBER HOSTEL COMMITTEE Sri Venkateswara College University of Delhi 01.Aug.2023 – 08.Oct.2025 –
ADMINISTRATIVE ASSIGNMENTS MEMBER PLACEMENT CELL Sri Venkateswara College University of Delhi 01.Jul.2023 – 30.Jun.2024 –
ADMINISTRATIVE ASSIGNMENTS MEMBER RESEARCH COMMITTEE Sri Venkateswara College University of Delhi 01.Jul.2023 – 30.Jun.2025 –
CAREER PROFILE ASSOCIATE PROFESSOR DEPARTMENT OF BIOCHEMISTRY Sri Venkateswara College 11.Jun.2019 – Till date –
CAREER PROFILE ASSISTANT PROFESSOR DEPARTMENT OF BIOCHEMISTRY Sri Venkateswara College 10.Jun.2014 – 10.Jun.2019 –
CAREER PROFILE OTHERS OTHERS The Biodesign Institute at Arizona State University 10.Feb.2010 – 21.May.2013 –
CAREER PROFILE POST DOCTORATE OTHERS The Biodesign Institute at Arizona State University 01.Jul.2005 – 10.Feb.2010 –
Other Profiles & Specializations

No specializations published.

Research Guidance
YearGuide ForTitle of Thesis / DissertationScholar NameStatusAttachment
2028 Ph. D. Dissecting TCS-Pkn Signaling Networks in Mycobacterium tuberculosis Abhishek Garg Pursuing –
2027 Ph. D. Understanding the regulation of toxin antitoxin systems of M. tuberculosis Shafinaz Rahman Sarah Pursuing –
Publications
CategoryJournal / ConferenceTitleAuthor(s)Month / YearAttachment
JOURNAL PAPER
International
RelK, a YoeB-like toxin from Mycobacterium tuberculosis displays ribosome independent endonucleolytic activity Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Shafinaz Rahman Sarah a b , Nimisha Sinha a , Harsh A. Gandhi c , Jaydeep Bhattacharya c, Vandana Malhotra
Corresponding Author
February 2026
JOURNAL PAPER
International
Tamoxifen inhibits histidine kinases of M. tuberculosis two-component signaling systems Microbiology Spectrum / ASM Abhishek Garghttps, Devendra Pratap Singh, Mansi Pandit, Vandana Malhotra, Deepak Kumar Saini
Corresponding Author
February 2026
CHAPTER
International
Essential Laboratory Techniques and Biochemical Analysis Taylor and Francis Vandana Malhotra
Sole Author
September 2025
JOURNAL PAPER
International
Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization mBio Shafinaz Rahman Sarah, Abhishek Garg, Sadiyah Afroz, Shaleen Korch, Arjun Ray, Amita Gupta, Vandana Malhotra
Corresponding Author
June 2025
JOURNAL PAPER
International
Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates Journal of Visualized Experiments Hiba Haris, Prachi Kumar, Vivek Bhardwaj, Sidhartha Taritla, Vandana Malhotra, Nandita Narayanasamy
Corresponding Author
October 2024
JOURNAL PAPER
National
In silico evidence for extensive Ser/Thr phosphorylation of Mycobacterium tuberculosis two-component signalling systems Current Science Abhishek Garg, Nimisha Khurana, Ananya Chugh, Kangna Verma, Vandana Malhotra
Corresponding Author
November 2022
JOURNAL PAPER
International
Mycobacterium tuberculosis PknK substrate profiling reveals essential transcription terminator protein Rho and two-component response regulators PrrA and MtrA as novel targets for phosphorylation Microbiology Spectrum Vandana Malhotra, Blessing P Okon, Akash T Satsangi, Sumana Das, Uchenna Watson Waturuocha, Atul Vashist, Josephine E Clark-Curtiss, Deepak Kumar Saini
First Author, Corresponding Author
April 2022
JOURNAL PAPER
International
A high-frequency single nucleotide polymorphism in the MtrB sensor kinase in clinical strains of Mycobacterium tuberculosis alters its biochemical and physiological properties PLos One D. K. Waturuocha, U. W., P. J., A., Singh, K. K., Malhotra, V., Krishna, M. S., & Saini
Joint Author
September 2021
JOURNAL PAPER
International
A low-prevalence single-nucleotide polymorphism in the Sensor kinase PhoR in Mycobacterium tuberculosis suppresses its autophosphatase activity and reduces pathogenic fitness: implications in Evolutionary Selection Frontiers in Microbiology Uchenna Watson Waturuocha, MS Krishna, Vandana Malhotra, Narendra M Dixit, Deepak Kumar Saini
Joint Author
August 2021
JOURNAL PAPER
International
Cyclic di‐GMP sensing histidine kinase PdtaS controls mycobacterial adaptation to carbon sources The FASEB journal Vignesh Narayan Hariharan, Rahul Yadav, Chandrani Thakur, Albel Singh, Renu Gopinathan, Devendra Pratap Singh, Gaurav Sankhe, Vandana Malhotra, Nagasuma Chandra, Apoorva Bhatt, Deepak Kumar Saini
Joint Author
March 2021
JOURNAL PAPER
International
Acetylation of Response Regulator Proteins, TcrX and MtrA in M. tuberculosis Tunes their Phosphotransfer Ability and Modulates Two-Component Signaling Crosstalk Journal of Molecular Biology Krishna Kumar Singh, Neerupma Bhardwaj, Gaurav D Sankhe, Niveda Udaykumar, Rambir Singh, Vandana Malhotra, Deepak Kumar Saini
Joint Author
February 2019
JOURNAL PAPER
International
Interplay of PhoP and DevR response regulators defines expression of the dormancy regulon in virulent Mycobacterium tuberculosis Journal of Biological Chemistry Atul Vashist, Vandana Malhotra, Gunjan Sharma, Jaya Sivaswami Tyagi, Josephine E Clark-Curtiss
First Author, Corresponding Author
October 2018
CHAPTER
National
Life Science Protocol Manual Department of Biotechnology Govt of India Vandana Malhotra and Meeta Bhardwaj
First Author
January 2018
CHAPTER
National
Life Science Protocol Manual Department of Biotechnology Govt of India Nandita Narayanasamy, Vandana Malhotra
Joint Author
January 2018
JOURNAL PAPER
International
The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition Journal of Microbiology Shaleen B Korch, Vandana Malhotra, Heidi Contreras, Josephine E Clark-Curtiss
Joint Author
December 2015
JOURNAL PAPER
International
Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism Journal of Biological Chemistry Vandana Malhotra, Ruchi Agrawal, Tammi R Duncan, Deepak K Saini, Josephine E Clark-Curtiss
First Author, Corresponding Author
March 2015
JOURNAL PAPER
International
Mycobacterium tuberculosis protein kinase K enables growth adaptation through translation control Journal of Bacteriology Vandana Malhotra, Blessing P Okon, Josephine E Clark-Curtiss
First Author, Corresponding Author
August 2012
JOURNAL PAPER
International
The prrAB Two-Component System Is Essential for Mycobacterium tuberculosis Viability and Is Induced under Nitrogen-Limiting Conditions Journal of Bacteriology Shelley E Haydel, Vandana Malhotra, Garrett L Cornelison, Josephine E Clark-Curtiss
Joint Author
January 2012
JOURNAL PAPER
International
Mycobacterium tuberculosis protein kinase K confers survival advantage during early infection in mice and regulates growth in culture and during persistent infection: implications for immune modulation Microbiology Vandana Malhotra, Lourdes T Arteaga-Cortes, Gwendolyn Clay, Josephine E Clark-Curtiss
First Author, Corresponding Author
September 2010
JOURNAL PAPER
International
DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: Links to asparagine metabolism Tuberculosis Vandana Malhotra, Jaya Sivaswami Tyagi, Josephine E Clark-Curtiss
First Author, Corresponding Author
March 2009
JOURNAL PAPER
International
Cross Talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis FEBS Letters Saini, D. K., V. Malhotra, J.S. Tyagi.
Joint Author
April 2004
JOURNAL PAPER
International
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia responsive in the absence of the DNA binding domain of DevR. Microbiology 19. Saini, D. K., V. Malhotra, D. Dey, N. Pant, T. K. Das and J. S. Tyagi.
Joint Author
April 2004
JOURNAL PAPER
International
Disruption of response regulator gene, devR leads to attenuation in virulence of Mycobacterium tuberculosis FEMS Microbiology Letters Vandana Malhotra, Deepak Sharma, VD Ramanathan, H Shakila, Deepak K Saini, Soumitesh Chakravorty, Taposh K Das, Qing Li, Richard F Silver, PR Narayanan, Jaya Sivaswami Tyagi
First Author
February 2004
JOURNAL PAPER
International
Characterization of a two-component System, devR-devS, of Mycobacterium tuberculosis Tubercle and Lung Disease 21. Dasgupta, N., V. Kapur, K.K. Singh, T. K. Das, S. Sachdeva, K. Jyothisri and J. S. Tyagi
Joint Author
May 2000
Research Projects
YearTitle of ProjectSponsoring AgencyDurationAmount SanctionedAttachment
2012 High-throughput substrate profiling for Mycobacterium tuberculosis Protein Kinase K using Tuberculosis (TB)-Nucleic Acid Programmable Protein array (NAPPA) technology Arizona Community foundation 12 months 20,000 usd
2015 High-throughput substrate profiling of Mycobacterium tuberculosis Ser/Thr Protein kinase K Department of Biotechnology, Govt of India 3 years 45.0 Lakhs
2016 To Develop Novel FRET Based Tools for Detecting In Vivo Localization & Phosphorylation of M. tuberculosis Signaling Proteins Cluster Innovation Center, DU 3 years 20.14 Lakhs
2016 Delayed Sleep Phase Disorder (DSPD): A Public Health Initiative Targeting Youth in Urban Areas, Creating Socio-Legal Awareness and Development of a Rapid Mobile Diagnostic Test Cluster Innovation Center, DU 3 years 24 Lakhs
2021 Understanding the Role of Ser/Thr Protein Kinases in the regulation of Toxin-Antitoxin loci in Mycobacterium tuberculosis Department of Biotechnology, Govt of India 3 years 123 Lakhs
Books

No books published.

Faculty Achievements
YearCategoryRoleLevelName / EventDate From – ToAttachment
2025 INVITED LECTURES/ RESOURCE PERSON/ PAPER PRESENTATIONS ATTENDED INVITED SPEAKER National Recent Frontiers in Disease Biology: Latest Innovations and Biotechnological Solutions 21.Jul.2025 – 25.Jul.2025
2025 INVITED LECTURES/ RESOURCE PERSON/ PAPER PRESENTATIONS ATTENDED INVITED SPEAKER National Biosafety Training 14.May.2025 – 14.May.2025
2025 SHORT TERM COURSE RESOURCE PERSON College SVC गुरुकु ल: विद्यालय सेमहाविद्यालय तक 11.Feb.2025 – 12.Feb.2025
2021 FACULTY DEVELOPMENT PROGRAM ATTENDED RESOURCE PERSON National Digital Pedagogy and Climate Change education across disciplines 28.Aug.2021 – 28.Aug.2021